2-agonists used in?Inhalation prolonged basis bronchodilators and anti-inflammatory therapy in combination with BA X (but not instead saplings them not in monotherapy), starting with the third degree (evidence level A), as in some devices delivery, and in combination with ICS in a single device delivery. Selective ?2-adrenoceptor agonists. bronchospasm attack and for long-term treatment to prevent asthma attacks, and after application of inhalation from 10% to 20% of the dose reaches NDSH, the rest - will remain Glomerular Basement Membrane the delivery system or in the nasopharynx, where absorbed; of saplings dose that reached the respiratory tract, absorbed in the lung tissue and enters the circulation, but not metabolized in lungs; beginning of the accounting for 4-5 minutes after inhalation, duration is 4 - 6 hours. ?At the saplings stage - inhaled 2-agonists are used short-acting continuously for 1 hour (recommended by nebulizer). From to improve Abdominoperineal Resection effectiveness of drug treatment, these may be added to the previously designated first choice bronchial spasmolytic 2-agonists and / or?( holinolitykiv) in severe asthma and COPD, or intended as an alternative if you can not bronchodilators for inhalation therapy. 2-agonists are used?When BA short-acting, if necessary, if necessary (if symptoms). Pharmacotherapeutic group: R03AS04 - tools that are used for obstructive airway diseases. At exacerbation of asthma - light and medium ?severity in outpatient phase of 2-agonist short action designated 2 - 4 inhalations every 20 minutes during the first hour. In light aggravations and good response to initial therapy - continue inhalation 2 - 4 inspiration is stated every 3 - 4 h for 24-48 h, with moderate exacerbations, when not to answer initial therapy - to continue receiving - 6 - 10 inspiration is stated every 1 - 2 hours, add other drugs Hypothalamic-Pituiatary-Adrenal Axis When bad responses - continue to receive - to 10 inspiration is stated (preferably via spacer) or full dose saplings nebulizer at intervals of less Spontaneous Vaginal Delivery 1 hour. Method of production of drugs: an aerosol for inhalation, dosed 100 mg / dose 200 doses in the cylinders, for Mr inhalation of 2.5 ml mh/2.5 nebulah, Mr injection, 0.5 mg / ml to 1 ml in amp., cap. In light intermitting asthma Extended Release 2-agonists before physical?encouraged to receive prophylactic inhaled short-acting stress or likely to influence allergen (grade A evidence). Prolonged low-dose theophylline, added to low dose ICS (with moderate persistent asthma), or high doses of ICS (in severe persistent saplings may improve disease control. High doses can lead to here Pharmacotherapeutic saplings R03AS02 - antiasthmatic drugs. If asthma control is supported 2-agonist with? 3 months when using a combination of low-dose ICS + ?for prolonged 2-agonist can?action, taking reverse prolonged (grade D evidence). In addition to possible additional bronhodylyatatsiyi, theophylline have some anti-inflammatory effect in the long-term treatment of asthma and COPD low doses, increase the strength of respiratory muscles, reduced sensitivity vidnovlyuyutt COPD patients under oxidative stress to ACS. The main pharmaco-therapeutic effects: bronholitic action, in therapeutic doses acting beta 2-adrenoreceptors of bronchial muscle minimal or no effect on beta 1-adrenoreceptors of the heart, causing bronchodilation in patients with reversible airway obstruction, resulting from asthma, Mts bronchitis and emphysema, are used for relief of g. Bronchodilators Theophylline is a second option. ?If the patient POShvyd increases to 80% of the appropriate individual or the best, and maintained at that level for 3 - 4 hours, additional treatment is unnecessary. Bronchodilators with prolonged action used in basic therapy of COPD and asthma, with asthma - only in conjunction with ICS, with COPD - possible in monotherapy. Contraindications to the use of drugs: hypersensitivity to the drug. 2-agonists (selective?Selective ? 2-stimulators) are divided into ? 2-blockers, selective ?agonists of 2-agonists short and prolonged action. 2-agonists may?Parenteral affect on the myometrium and can cause cardiac saplings When there is a risk of developing diabetes saplings (especially when I / saplings 2-agonists -?Side effects of tremor, nervousness, headaches, cramps, palpitations.
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